Actemra 200mg/10ml vial for i.v. inf
اكتيمرا 200مجم/10مل فيال للتسريب الوريدي
tocilizumabFrom the official published price list, updated twice a day. Pharmacies may differ slightly.
The medical information below is guidance and may be incomplete or wrong. Do not change your medicine or dose based on it — ask a pharmacist or doctor.
Uses
An IL-6 receptor antagonist indicated for moderately to severely active rheumatoid arthritis in adults inadequately responding to DMARDs, giant cell arteritis, polyarticular and systemic juvenile idiopathic arthritis, and cytokine release syndrome.
Do not use if
Contraindicated in patients with known hypersensitivity to tocilizumab products.
Side effects
Common adverse reactions include upper respiratory tract infections, nasopharyngitis, headache, hypertension, and elevated liver enzymes. Serious risks include severe infections, gastrointestinal perforations, neutropenia, thrombocytopenia, and hypersensitivity reactions including anaphylaxis.
Warnings
Boxed warning: patients are at increased risk of serious infections that may lead to hospitalization or death. Do not start treatment during active infection. Monitor for tuberculosis reactivation and opportunistic infections. Monitor liver enzymes, neutrophil, and platelet counts regularly.
How it works
Tocilizumab binds to both soluble and membrane-bound IL-6 receptors, inhibiting IL-6-mediated pro-inflammatory signaling. IL-6 is a pleiotropic cytokine involved in immune activation, acute-phase response, and hematopoiesis. Blockade reduces CRP, ESR, and inflammatory markers.
Storage
Refrigerate at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect vials and prefilled syringes from light.