Daxas 500 mcg 10 tabs
داكساس 500 ميكروجرام 10 أقراص
roflumilastFrom the official published price list, updated twice a day. Pharmacies may differ slightly.
Save 115 EGP (85%) with an identical equivalent
Same active ingredient, strength, form and pack size: Dalivent 0.5 mg 10 f.c. tabs (20 EGP)
The medical information below is guidance and may be incomplete or wrong. Do not change your medicine or dose based on it — ask a pharmacist or doctor.
Uses
Roflumilast is a selective phosphodiesterase-4 (PDE4) inhibitor indicated to reduce the risk of COPD exacerbations in patients with severe COPD associated with chronic bronchitis and a history of exacerbations. It is not a bronchodilator and is not indicated for acute bronchospasm.
Do not use if
Contraindicated in patients with moderate to severe liver impairment (Child-Pugh B or C). Avoid in patients with a history of depression or suicidality.
Side effects
The most common adverse effects include diarrhea, weight decrease, nausea, headache, back pain, influenza, insomnia, dizziness, and decreased appetite. Psychiatric events including suicidal ideation have been reported.
Warnings
Monitor for psychiatric symptoms including worsening of depression, insomnia, anxiety, and suicidal thoughts; inform patients, caregivers, and families. Unexplained weight loss should be evaluated. Not for use in acute bronchospasm. Use with caution in patients with a low body weight.
How it works
Roflumilast and its active N-oxide metabolite selectively inhibit PDE4, the major enzyme metabolizing cyclic AMP in lung tissue. This leads to accumulation of intracellular cyclic AMP, which suppresses the activity of inflammatory cells such as neutrophils and macrophages, reducing pulmonary inflammation.
Storage
Store at room temperature (20–25°C). Keep away from moisture and light.