Uses

Indicated as an adjunct to diet to reduce triglyceride levels in adults with severe hypertriglyceridemia (≥500 mg/dL). A purified ethyl ester of eicosapentaenoic acid (EPA).

Do not use if

Contraindicated in patients with known hypersensitivity to icosapent ethyl or any of its components. Use with caution in patients with fish or shellfish allergy.

Side effects

Common adverse effects include arthralgia, atrial fibrillation or flutter, and potential bleeding. Gastrointestinal symptoms and peripheral edema may also occur.

Warnings

Associated with increased risk of atrial fibrillation or atrial flutter requiring hospitalization, particularly in patients with prior history of these arrhythmias. May increase bleeding risk when used with anticoagulants.

How it works

Icosapent ethyl is a highly purified EPA ethyl ester that reduces hepatic VLDL-TG synthesis and secretion, enhances triglyceride clearance, and inhibits key enzymes in lipogenesis including acyl-CoA:diacylglycerol acyltransferase.

Storage

Store at room temperature between 20–25°C. Keep in original container.