bempetina 180 mg 30 f.c. tabs
بيمبيتينا 180 مجم 30 قرص
bempedoic acidThe published official price. Pharmacies may differ slightly.
- Strength
- 180mg
- Form
- tablet
- Manufacturer
- averroes pharma
- Route
- oral.solid
The medical information below is guidance and may be incomplete or wrong. Do not change your medicine or dose based on it — ask a pharmacist or doctor.
Uses
Indicated as an adjunct to diet and exercise to reduce LDL-cholesterol in adults with hypercholesterolemia, including heterozygous familial hypercholesterolemia. Also reduces the risk of major adverse cardiovascular events in adults unable to tolerate recommended statin therapy.
Do not use if
Contraindicated in patients with known hypersensitivity to bempedoic acid or any excipients. Serious hypersensitivity reactions including anaphylaxis and angioedema have been reported.
Side effects
Common side effects include upper respiratory tract infections, muscle spasms, hyperuricemia, and back pain. Tendon rupture is a rare but serious adverse effect. Elevated liver enzymes and new-onset atrial fibrillation have been reported.
Warnings
Monitor serum uric acid periodically; initiate urate-lowering therapy if hyperuricemia or gout develops. Risk of tendon rupture, particularly in patients also taking fluoroquinolones or corticosteroids. Perform liver function tests as clinically indicated.
How it works
Bempedoic acid is an ATP-citrate lyase (ACL) inhibitor that is converted to its active form by very-long-chain acyl-CoA synthetase 1 (ACSVL1), active only in the liver. By inhibiting ACL, it reduces cholesterol synthesis in hepatocytes, upregulates LDL receptors, and lowers plasma LDL-C without affecting skeletal muscle, reducing myopathy risk.
Storage
Store at controlled room temperature 20–25°C (68–77°F); excursions permitted to 15–30°C. Store in original package to protect from moisture.