depakine chrono 500mg 30 scored prolonged rel. f.c. tab
ديباكين كرونو 500مجم 30 قرص
sodium valproate+valproic acidThe published official price. Pharmacies may differ slightly.
- Strength
- 500 mg
- Form
- tablet
- Manufacturer
- sanofi winthrop > sanofi
- Route
- oral.solid
The medical information below is guidance and may be incomplete or wrong. Do not change your medicine or dose based on it — ask a pharmacist or doctor.
Uses
This combination is used for treatment of epilepsy (generalized, partial, and absence seizures) and as prophylaxis for migraine. It is also used as a mood stabilizer in bipolar disorder.
Do not use if
Contraindicated in known hepatic disease or significant hepatic dysfunction, mitochondrial disorders caused by POLG mutations, and known hypersensitivity to valproate. Absolutely contraindicated in pregnancy due to teratogenicity.
Side effects
Common side effects include nausea, tremor, weight gain, hair loss, and drowsiness. Serious risks include hepatotoxicity, pancreatitis, thrombocytopenia, and hyperammonemic encephalopathy.
Warnings
High risk of fetal harm (neural tube defects, cognitive impairment in offspring); females of childbearing potential must use effective contraception. Monitor liver function and complete blood count regularly. Risk of suicidal ideation as with all antiepileptics.
How it works
Valproic acid and its sodium salt increase GABA activity in the brain by inhibiting GABA transaminase and blocking voltage-gated sodium and calcium channels. This broad spectrum of action underlies its use across multiple seizure types.
Storage
Store below 25°C, protected from moisture and light. Keep in original packaging.