Uses

Used with diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Do not use if

Contraindicated in severe renal impairment, metabolic acidosis, and NYHA class III or IV heart failure.

Weight gain, edema, diarrhea, nausea, and hypoglycemia with certain combinations may occur.

Monitor for lactic acidosis, heart failure, edema, and liver dysfunction.

Combines metformin, which reduces hepatic glucose production, with pioglitazone, which improves insulin sensitivity.

Store at room temperature.