Uses

A non-opioid, non-NSAID centrally acting analgesic indicated for moderate to severe acute pain, including post-operative pain, musculoskeletal pain, and cancer-related pain. Available as an injection and oral formulation.

Do not use if

Contraindicated in patients with a history of convulsions or predisposition to seizures, and in patients with urinary retention or angle-closure glaucoma. Should not be used with monoamine oxidase inhibitors (MAOIs).

Side effects

Common side effects include nausea, vomiting, dry mouth, dizziness, sweating, and tachycardia. Urinary hesitancy and blurred vision may occur. Hallucinations and convulsions have been reported at high doses.

Warnings

Use with caution in patients with hepatic or renal impairment. The anticholinergic properties may worsen urinary retention, constipation, and glaucoma. Avoid abrupt discontinuation after prolonged use. Not recommended in patients with a history of epilepsy.

How it works

Nefopam is a centrally acting analgesic with a unique mechanism distinct from opioids and NSAIDs. It inhibits the reuptake of dopamine, noradrenaline, and serotonin in the central nervous system, thereby modulating pain transmission. It also has some sodium channel blocking activity.

Storage

Store ampoules at room temperature below 25°C, protected from light. Do not refrigerate.