bosentadin 62.5 mg 10 f.c. tabs
بوسنتادين 62.5 مجم 10 أقراص
bosentanThe published official price. Pharmacies may differ slightly.
- Strength
- 62.5 mg
- Form
- tablet
- Manufacturer
- eva pharma > biothecary
- Route
- oral.solid
The medical information below is guidance and may be incomplete or wrong. Do not change your medicine or dose based on it — ask a pharmacist or doctor.
Uses
Bosentan is an endothelin receptor antagonist indicated for treatment of pulmonary arterial hypertension (WHO Group 1) in adults to improve exercise capacity and delay clinical worsening, and in pediatric patients aged 3 years and older with idiopathic or congenital PAH.
Do not use if
Contraindicated in pregnancy due to teratogenicity, in patients receiving cyclosporine A or glyburide, and in those with known hypersensitivity to bosentan.
Side effects
Common adverse reactions (≥3% over placebo) include nasopharyngitis, flushing, leg edema, anemia, and elevated liver aminotransferases. Hepatotoxicity and fluid retention are important serious adverse effects.
Warnings
Black box warning: risk of hepatotoxicity (requires regular liver function monitoring) and embryo-fetal toxicity (requires pregnancy testing and contraception). Available only through a restricted REMS program.
How it works
Bosentan competitively antagonizes both ETA and ETB endothelin receptors with slightly higher affinity for ETA. By blocking endothelin-1 signaling, it reduces pulmonary vascular resistance and decreases pulmonary arterial pressure, improving hemodynamics.
Storage
Store at room temperature 20°C–25°C (68°F–77°F) in the original packaging.