Uses

Used to reduce LDL cholesterol and cardiovascular risk in patients with hypercholesterolemia or familial hypercholesterolemia. It is also used to reduce the risk of major cardiovascular events in high-risk adults.

Do not use if

Contraindicated in patients with a history of serious hypersensitivity reactions to evolocumab or its components.

Side effects

Common effects include nasopharyngitis, upper respiratory infections, influenza-like symptoms, back pain, and injection-site reactions.

Warnings

Serious hypersensitivity reactions including angioedema may occur. Discontinue treatment if significant allergic reactions develop.

How it works

A monoclonal antibody that inhibits PCSK9, increasing LDL receptor availability and enhancing clearance of LDL cholesterol from the blood.

Storage

Store refrigerated at 2°C to 8°C in the original carton. Do not freeze or shake.