thalix 50mg 30caps.(illegal import
ثاليكس 50مجم 30 كبسول مستورد
thalidomideThe published official price. Pharmacies may differ slightly.
- Strength
- 50 mg
- Form
- capsule
- Manufacturer
- fresenius kabi >
- Route
- oral.solid
The medical information below is guidance and may be incomplete or wrong. Do not change your medicine or dose based on it — ask a pharmacist or doctor.
Uses
Indicated in combination with dexamethasone for treatment of newly diagnosed multiple myeloma, and as acute and maintenance therapy for the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL).
Do not use if
Absolutely contraindicated in pregnancy due to severe teratogenicity causing birth defects or embryo-fetal death. Contraindicated in patients with known hypersensitivity to thalidomide or its components.
Side effects
Major adverse effects include severe teratogenicity causing birth defects, venous and arterial thromboembolism, peripheral neuropathy, drowsiness, and constipation. Increased risk of mortality has been reported in some patient populations.
Warnings
Carries a boxed warning for embryo-fetal toxicity and venous thromboembolism. Must only be prescribed under a strict risk management program (REMS in the US). Male patients must also use contraception. Regular neurological monitoring is required.
How it works
Thalidomide exerts immunomodulatory, anti-inflammatory, and antiangiogenic effects mediated through its target protein cereblon, a component of a cullin ring E3 ubiquitin ligase complex. The exact mechanism of action is not fully elucidated.
Storage
Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C. Protect from light. Must not be repackaged.