Uses

Used to reduce the risk of stroke in patients with a history of transient ischemic attack or completed ischemic stroke. Also used as a coronary vasodilator and as an antiplatelet agent.

Do not use if

Contraindicated in patients with known hypersensitivity to dipyridamole. Use with caution in patients with severe coronary artery disease, hypotension, or coagulation disorders.

Side effects

Common adverse effects include headache, dyspepsia, abdominal pain, nausea, and diarrhea. Dizziness and flushing may also occur.

Warnings

Increases risk of bleeding, especially when used concomitantly with anticoagulants or antiplatelet agents. Avoid use in patients with severe hepatic or renal insufficiency. Interrupt use before intravenous dipyridamole stress testing.

How it works

Dipyridamole inhibits adenosine uptake into platelets, endothelial cells, and erythrocytes, and also inhibits phosphodiesterase activity, increasing intracellular cyclic AMP and cyclic GMP. This results in reduced platelet aggregation and coronary vasodilation.

Storage

Store at room temperature between 15–30°C. Protect from moisture and excessive heat. Keep in original container.