Sutent 12.5mg 28 capsules
سوتنت 12.5مجم 28 كبسول
sunitinibFrom the official published price list, updated twice a day. Pharmacies may differ slightly.
Save 3763 EGP (55%) with an identical equivalent
Same active ingredient, strength, form and pack size: Suninevel 12.5mg 28 caps (3137 EGP)
The medical information below is guidance and may be incomplete or wrong. Do not change your medicine or dose based on it — ask a pharmacist or doctor.
Uses
Sunitinib is a multi-targeted kinase inhibitor indicated for gastrointestinal stromal tumor (GIST) after imatinib failure, advanced renal cell carcinoma (RCC), adjuvant treatment of high-risk RCC following nephrectomy, and progressive well-differentiated pancreatic neuroendocrine tumors (pNET).
Do not use if
No absolute contraindications are listed in the FDA labeling. However, it should be used with extreme caution in patients with significant hepatic impairment, history of QT prolongation, or pre-existing cardiovascular disease.
Side effects
Common side effects include fatigue, diarrhea, nausea, mucositis, hand-foot syndrome, hypertension, myelosuppression, and skin discoloration. Serious adverse effects include hepatotoxicity, cardiovascular events, QT prolongation, hemorrhage, and thyroid dysfunction.
Warnings
Carries a boxed warning for potentially severe and fatal hepatotoxicity; liver function must be monitored throughout therapy. Monitor for cardiovascular events, hypertension, bleeding, and thyroid function. Embryo-fetal toxicity is a concern; effective contraception is required.
How it works
Sunitinib inhibits multiple receptor tyrosine kinases (RTKs) including PDGFR, VEGFR, KIT, FLT3, and RET. By blocking these receptors, it inhibits tumor cell proliferation, pathologic angiogenesis, and metastatic progression.
Storage
Store at room temperature (20–25°C). Dispense in a tight container.