Uses

A fourth-generation cephalosporin antibiotic used to treat serious bacterial infections including hospital-acquired pneumonia, urinary tract infections, septicemia, febrile neutropenia, and skin and soft tissue infections caused by susceptible organisms.

Do not use if

Contraindicated in patients with known hypersensitivity to cephalosporins. Use with caution in patients with penicillin allergy due to possible cross-reactivity.

Side effects

Common side effects include diarrhea, nausea, skin rash, and injection site reactions. Serious risks include hypersensitivity reactions, Clostridioides difficile-associated diarrhea, and encephalopathy with high doses.

Warnings

Use with caution in patients with renal impairment; dose adjustment is required. Risk of Clostridioides difficile-associated diarrhea during or after therapy. Monitor for signs of CNS toxicity, especially in patients with renal failure.

How it works

Cefpirome is a fourth-generation cephalosporin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. It has broad-spectrum activity against both Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa, and is stable to many beta-lactamases.

Storage

Store the dry powder below 25°C, protected from light. Reconstituted solutions should be used immediately or stored in a refrigerator for a limited period per product labeling.