Uses

This fixed combination of chlorzoxazone (a centrally acting muscle relaxant) and ibuprofen (an NSAID) is indicated for the symptomatic relief of acute musculoskeletal pain, muscle spasm, and associated inflammation, such as in low back pain, neck pain, and muscle injuries.

Do not use if

Contraindicated in patients with known hypersensitivity to either component, aspirin-sensitive asthma, active peptic ulcer disease, severe hepatic or renal impairment, or significant heart failure. NSAIDs are contraindicated in the third trimester of pregnancy.

Side effects

Chlorzoxazone may cause drowsiness, dizziness, and rarely hepatotoxicity. Ibuprofen may cause gastrointestinal side effects (dyspepsia, peptic ulcers, bleeding), fluid retention, elevated blood pressure, and increased cardiovascular risk with prolonged use. Hypersensitivity reactions can occur.

Warnings

Chlorzoxazone may cause sedation; patients should avoid driving or operating machinery. Monitor liver function with prolonged use. Ibuprofen should be used at the lowest effective dose for the shortest duration. Concomitant use of alcohol or other CNS depressants with chlorzoxazone increases sedation risk.

How it works

Chlorzoxazone acts centrally on the spinal cord and subcortical areas to depress multisynaptic reflexes involved in producing and maintaining skeletal muscle spasm. Ibuprofen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis and thereby decreasing inflammation, pain, and fever.

Storage

Store below 25°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.