Uses

Used for complicated intra-abdominal infections with metronidazole, complicated urinary tract infections including pyelonephritis, and hospital-acquired or ventilator-associated bacterial pneumonia caused by susceptible organisms.

Do not use if

Contraindicated in patients with serious hypersensitivity to ceftolozane, tazobactam, piperacillin/tazobactam, or other beta-lactam antibiotics.

Side effects

Common adverse effects include nausea, diarrhea, headache, fever, and infusion-related reactions. Serious hypersensitivity and Clostridioides difficile-associated diarrhea may occur.

Warnings

Monitor renal function and adjust dosage when needed. Watch for severe hypersensitivity reactions and antibiotic-associated diarrhea.

How it works

Ceftolozane inhibits bacterial cell wall synthesis while tazobactam inhibits beta-lactamases that can inactivate certain antibiotics.

Storage

Store refrigerated at 2–8°C and protect from light.