Uses

Eprosartan is an angiotensin II receptor blocker (ARB) indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.

Do not use if

Contraindicated in patients with known hypersensitivity to eprosartan. Contraindicated in combination with aliskiren in patients with diabetes or renal impairment (GFR <60 ml/min). Avoid in pregnancy due to risk of fetal harm.

Side effects

Common adverse effects include upper respiratory tract infections, rhinitis, pharyngitis, cough, and dizziness. Hyperkalemia may occur, particularly in patients with renal impairment or on potassium-sparing diuretics. Rarely, angioedema has been reported.

Warnings

Avoid use in pregnancy (second and third trimesters) due to risk of fetal renal damage and death. Monitor renal function, serum electrolytes, and blood pressure regularly. Use with caution in patients with renal artery stenosis or severe renal impairment.

How it works

Eprosartan selectively blocks angiotensin II (type AT1 receptor), preventing its vasoconstrictive and aldosterone-stimulating effects. This results in vasodilation and reduction in blood pressure without affecting bradykinin metabolism, which distinguishes it from ACE inhibitors.

Storage

Store at room temperature 20°C to 25°C (68°F to 77°F), protected from moisture.