Uses

Indicated for the treatment of ovulatory dysfunction in women who desire pregnancy, including conditions such as polycystic ovary syndrome, amenorrhea-galactorrhea syndrome, and secondary amenorrhea of undetermined etiology.

Do not use if

Contraindicated in patients with liver disease, existing ovarian cysts (not polycystic ovaries), abnormal uterine bleeding of undetermined origin, pregnancy, and known hypersensitivity to clomiphene.

Side effects

Common side effects include hot flushes, abdominal discomfort and distension, nausea, visual disturbances, and breast tenderness. Ovarian hyperstimulation syndrome (OHSS) is a serious complication, especially with higher doses.

Warnings

Patients should be warned about visual disturbances; if they occur, treatment should be discontinued. The risk of multiple gestation is increased. Do not use beyond six treatment cycles. Ovarian hyperstimulation syndrome requires immediate medical attention.

How it works

Clomiphene is a selective estrogen receptor modulator (SERM) that acts as an estrogen antagonist at the hypothalamus and pituitary, blocking negative feedback and stimulating increased gonadotropin (FSH and LH) secretion, thereby inducing ovarian follicular development and ovulation.

Storage

Store at controlled room temperature between 15°C and 30°C, away from heat, light, and excessive moisture. Keep in the original container.