mixmazil 14/10 mg 28 ext. rel. caps
ميكسمازيل 1410 مجم 28 كبسولة
memantine+donepezilThe published official price. Pharmacies may differ slightly.
- Strength
- 14/10 mg
- Form
- tablet
- Manufacturer
- hikma pharma
- Route
- oral.solid
The medical information below is guidance and may be incomplete or wrong. Do not change your medicine or dose based on it — ask a pharmacist or doctor.
Uses
The combination of donepezil and memantine is indicated for the treatment of moderate to severe dementia of the Alzheimer's type in patients already stabilised on donepezil 10 mg once daily. It combines an acetylcholinesterase inhibitor with an NMDA receptor antagonist for a complementary approach to managing Alzheimer's disease.
Do not use if
Contraindicated in patients with known hypersensitivity to memantine, donepezil, piperidine derivatives, or any excipients in the formulation.
Side effects
Common adverse effects include nausea, vomiting, diarrhoea, dizziness, headache, and insomnia. Serious reactions may include cardiac arrhythmias with vagotonic effects, peptic ulcer disease, gastrointestinal bleeding, and urinary retention.
Warnings
May exaggerate succinylcholine-type muscle relaxation during anaesthesia. Vagotonic effects may cause bradycardia or syncope. Patients should be monitored for signs of active gastrointestinal bleeding, urinary retention, and seizures. Use with caution in patients with severe renal impairment.
How it works
Donepezil reversibly inhibits acetylcholinesterase, increasing synaptic acetylcholine levels to enhance cholinergic neurotransmission. Memantine is a non-competitive NMDA receptor antagonist that reduces pathological glutamate excitotoxicity without interfering with normal synaptic glutamate signalling, providing neuroprotective effects in Alzheimer's disease.
Storage
Store at controlled room temperature, typically 15°C to 30°C (59°F to 86°F), in the original packaging.