Uses

Anthracycline antineoplastic used as part of combination chemotherapy for acute myeloid leukemia in adults.

Do not use if

No specific contraindications are listed in the referenced labeling.

Side effects

Serious adverse effects include cardiomyopathy, severe myelosuppression, tissue injury from extravasation, tumor lysis syndrome, and secondary malignancies.

Warnings

Monitor cardiac function, blood counts, and infusion sites closely. Serious cardiotoxicity can occur during or after treatment.

How it works

Interacts with DNA, inhibits topoisomerase II, and generates free radicals that damage cancer cells.

Storage

Store according to product labeling and protect from inappropriate temperatures.