engilor 5/500 mg 30 tab
انجيلور 5/ 500 مجم 30 قرص
glipizide+metforminThe published official price. Pharmacies may differ slightly.
- Strength
- 5/500mg
- Form
- tablet
- Manufacturer
- marcyrl co.
- Route
- oral.solid
The medical information below is guidance and may be incomplete or wrong. Do not change your medicine or dose based on it — ask a pharmacist or doctor.
Uses
Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus, combining the insulin secretagogue glipizide with the insulin sensitizer metformin.
Do not use if
Contraindicated in severe renal impairment (eGFR below 30 mL/min/1.73 m²), known hypersensitivity to either component, acute or chronic metabolic acidosis including diabetic ketoacidosis, and type 1 diabetes.
Side effects
Common side effects include diarrhea, nausea, and vomiting (mostly from metformin), and hypoglycemia (from glipizide). Rare but serious risk of lactic acidosis with metformin, particularly in renal impairment.
Warnings
Metformin-associated lactic acidosis, though rare, can be fatal. Risk increases with renal impairment, hepatic disease, congestive heart failure, and dehydration. Withhold before procedures using iodinated contrast media. Monitor renal function regularly.
How it works
Glipizide stimulates pancreatic insulin secretion via closure of beta-cell ATP-sensitive potassium channels. Metformin reduces hepatic glucose production, decreases intestinal glucose absorption, and improves peripheral insulin sensitivity. Their complementary mechanisms provide additive glycemic control.
Storage
Store at 20°C to 25°C (68°F to 77°F). Dispense in a tight container.