Uses

Topical antibacterial cream used for the prevention and treatment of infections in burns, wounds, and skin ulcers. The combination provides broad-spectrum coverage against gram-positive and gram-negative bacteria as well as Candida species.

Do not use if

Contraindicated in patients with hypersensitivity to sulfonamides, chlorhexidine, or silver compounds. Avoid use in premature infants and neonates. Avoid use near the eyes.

Side effects

Skin reactions including burning, itching, and rash may occur at the application site. Leukopenia has been reported with extensive use of silver sulfadiazine. Allergic reactions to sulfonamides are possible.

Warnings

Monitor blood counts with extensive application over large burn areas. Use with caution in patients with sulfonamide allergy or glucose-6-phosphate dehydrogenase (G6PD) deficiency. Avoid prolonged use without medical supervision.

How it works

Silver sulfadiazine releases silver ions that interfere with bacterial DNA and disrupts cell membranes. Chlorhexidine binds to bacterial cell walls causing lysis. Together they provide synergistic broad-spectrum antimicrobial activity.

Storage

Store below 25°C, away from light and heat. Do not freeze. Keep the tube tightly closed after use.