Uses

Orphenadrine is used for the relief of discomfort associated with acute painful musculoskeletal conditions. It also has an adjunct role in Parkinson's disease due to its anticholinergic properties.

Do not use if

Glaucoma, obstructive uropathy, achalasia, myasthenia gravis, stenosing peptic ulcer, and hypersensitivity to orphenadrine. Avoid concurrent use with propoxyphene.

Side effects

Dry mouth, blurred vision, urinary retention, constipation, tachycardia, dizziness, and drowsiness are common anticholinergic effects. Central nervous system excitation may occur at high doses.

Warnings

Use with caution in the elderly due to fall risk and cognitive effects. Avoid in patients with cardiovascular disease. May impair the ability to drive or operate machinery.

How it works

Orphenadrine is a centrally acting skeletal muscle relaxant and antimuscarinic agent. It reduces spasm by inhibiting central polysynaptic reflexes. Its anticholinergic activity is comparable to diphenhydramine. It also has mild analgesic and euphoric properties.

Storage

Store below 25°C in a dry place away from light. Keep out of reach of children.