salazopyrine 500mg 20 en-tab
سالازوبيرين 500مجم 20 قرص
sulphasalazineThe published official price. Pharmacies may differ slightly.
- Strength
- 500 mg
- Form
- tablet
- Manufacturer
- kahira > pfizer
- Route
- oral.solid
The medical information below is guidance and may be incomplete or wrong. Do not change your medicine or dose based on it — ask a pharmacist or doctor.
Uses
Sulphasalazine is used to treat ulcerative colitis and Crohn's disease, helping to reduce bowel inflammation. It is also used in the management of rheumatoid arthritis as a disease-modifying antirheumatic drug (DMARD).
Do not use if
Contraindicated in patients with hypersensitivity to sulphasalazine, sulfonamides, or salicylates. Also contraindicated in patients with intestinal or urinary obstruction and in those with porphyria.
Side effects
Common side effects include nausea, vomiting, headache, loss of appetite, and skin rash. It may also cause reversible oligospermia in men and, rarely, hepatotoxicity or blood dyscrasias.
Warnings
Regular monitoring of complete blood count and liver function tests is recommended during therapy. Use with caution in patients with G6PD deficiency, renal or hepatic impairment. Patients should maintain adequate hydration to prevent crystalluria.
How it works
Sulphasalazine is cleaved by colonic bacteria into sulfapyridine and 5-aminosalicylic acid (5-ASA). The 5-ASA component exerts local anti-inflammatory effects in the gut by inhibiting prostaglandin synthesis and modulating immune responses.
Storage
Store at room temperature (15–30°C), protected from light and moisture. Keep out of reach of children.