Uses

PARP inhibitor used for maintenance and treatment of selected BRCA-mutated or homologous recombination repair-deficient cancers, including ovarian and related gynecologic cancers.

Do not use if

No specific contraindications are listed in the referenced labeling.

Side effects

Common effects include nausea, fatigue, anemia, decreased appetite, and blood count abnormalities. Serious risks include MDS/AML, pneumonitis, thromboembolism, and liver injury.

Warnings

Monitor blood counts regularly. Watch for signs of bone marrow disorders, lung toxicity, thrombosis, and hepatic injury.

How it works

Olaparib inhibits PARP enzymes involved in DNA repair, leading to accumulation of DNA damage and death of susceptible tumor cells.

Storage

Store according to labeled conditions at controlled room temperature and keep in original packaging.