pyrazinamide 500mg u.s.p.27 20 tab
بيرازيناميد 500مجم 20 قرص
pyrazinamideThe published official price. Pharmacies may differ slightly.
- Strength
- 500 mg
- Form
- tablet
- Manufacturer
- memphis
- Route
- oral.solid
The medical information below is guidance and may be incomplete or wrong. Do not change your medicine or dose based on it — ask a pharmacist or doctor.
Uses
Pyrazinamide is indicated as part of combination antitubercular therapy for the initial treatment of active tuberculosis in adults and children. The standard regimen includes pyrazinamide with isoniazid and rifampicin for the first two months of a six-month course.
Do not use if
Contraindicated in patients with severe hepatic damage, known hypersensitivity to pyrazinamide, and in those with acute gout.
Side effects
The principal adverse effect is hepatotoxicity, which is dose-related. Other reactions include gastrointestinal disturbances (nausea, vomiting, anorexia), hyperuricemia leading to gout, thrombocytopenia, sideroblastic anemia, fever, and dysuria.
Warnings
Baseline and periodic liver function tests and serum uric acid measurements are required. Use with caution in patients with pre-existing liver disease or a history of alcohol use disorder. Discontinue if signs of hepatotoxicity appear.
How it works
Pyrazinamide is a nicotinamide analogue that is converted to pyrazinoic acid by mycobacterial pyrazinamidase. It is bactericidal against Mycobacterium tuberculosis in an acidic environment. It is well absorbed orally, widely distributed including into the CSF, and metabolized hepatically.
Storage
Store at controlled room temperature, protected from moisture and light.